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These vesicles then merge with the cell membrane, which releases the collagen into the space outside the cell. The basement membrane is made up of various proteins, and a large protein called Collagen IV is the most abundant component.Ĭollagen IV is made inside cells and packaged into bubble-like compartments called vesicles.
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In animals, so-called ‘basement membranes’ surround organs and help to both anchor certain tissue types together and control which molecules move between them. It also places fibrotic deposits both downstream and upstream of immune signaling, consistent with the chronic character of fibrotic diseases. Our work indicates that traffic imbalances and PM topology may contribute to fibrosis. Finally, we show that trimeric Collagen accumulation, downstream of Toll or endocytic defects, activates a tissue damage response. Deposits also form in the absence of negative Toll immune regulator Cactus, excess PM being caused in this case by increased secretion. We found that loss of Dynamin and other endocytic components causes pericellular trapping of outgoing Collagen IV due to dramatic cortex expansion when endocytic removal of PM is prevented. Here we show that plasma membrane (PM) overgrowth causes pericellular Collagen accumulation in Drosophila adipocytes.
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Little is known about the factors that determine preferential onset of fibrosis in particular tissues. Many chronic diseases are associated with fibrotic deposition of Collagen and other matrix proteins.